1928724-23-5

1928724-23-5 structure

1928724-23-5 structure

Name: SK33
Chemical Name: SK33
CAS Number: 1928724-23-5
Molecular Formula: C₂₀H₁₃F₉N₂O₃
Molecular Weight: 500.31
Catalog: Signaling Pathways Others Androgen Receptor
Create Date: 2020-04-14 22:46:00
Modify Date: 2024-01-15 23:39:32
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].

Name	SK33

Description	SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
In Vitro	In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1]. Cell Viability Assay[1] Cell Line: LNCaP/BicR cells Concentration: 0.1-100 μM Incubation Time: 96 hours Result: Results in a dose-dependent response and an inhibition of cell growth.
In Vivo	SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. Animal Model: ARE-Luc mice[1] Dosage: 50 mg/kg Administration: Subcutaneously; 24 hours Result: Inhibited AR transcriptional activity.
References	[1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.

Molecular Formula	C₂₀H₁₃F₉N₂O₃
Molecular Weight	500.31