Name | Tucotuzumab |
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Description | Tucotuzumab (Anti-EPCAM Recombinant Antibody) is a protein composed of an IgG1 monoclonal antibody specific for the human Epithelial Cell Adhesion Molecule (EpCAM) antigen, linked to two molecules of IL-2. Tucotuzumab is an immunosuppressant and antineoplastic agent[1]. |
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Related Catalog | |
In Vitro | Tucotuzumab 靶向肿瘤并通过 IL-2 应答性免疫细胞刺激抗肿瘤免疫反应,以及通过其 Fc 受体刺激免疫细胞[1]。 |
In Vivo | Tucotuzumab (75 μg; 瘤内注射; 每日 5 次,每次15 μg (总剂量 75 μg),各用50 μL PBS; 在第 10 天和第 14 天),肿瘤生长抑制显著增强,生存率提高[1]。 Animal Model: Female Balb/c mice bearing CT26-KS colon adenocarcinoma[1] Dosage: 75 μg Administration: Intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14 Result: Resulted in significantly greater tumor growth suppression and enhanced survival. |
References |
No Any Chemical & Physical Properties |