119817-90-2

119817-90-2 structure

Name: Dexloxiglumide
Chemical Name: (4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
CAS Number: 119817-90-2
Molecular Formula: C₂₁H₃₀Cl₂N₂O₅
Molecular Weight: 461.37900
Catalog: Signaling Pathways GPCR/G Protein Cholecystokinin Receptor
Create Date: 2018-06-13 17:43:17
Modify Date: 2024-01-08 20:41:42
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].

Name	(4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
Synonyms	CR-2017 Dexloxiglumida [INN-Spanish] Dexloxiglumidum [INN-Latin] Dexloxiglumidum Dexloxiglumida Dexloxiglumide

Description	Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Metabolic Disease
References	[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. [2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

Hazard Codes	Xn,Xi