Robotnikinin
Modify Date: 2024-01-15 13:40:06
Robotnikinin structure
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Common Name | Robotnikinin | ||
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| CAS Number | 1132653-79-2 | Molecular Weight | 454.95 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H27ClN2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RobotnikininRobotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2]. |
| Name | Robotnikinin |
|---|---|
| Synonym | More Synonyms |
| Description | Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2]. Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3]. Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4]. RT-PCR[4] Cell Line: NCI-H929 or U266 cells. Concentration: 5 μM. Incubation Time: 48 h. Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells. |
| References |
| Molecular Formula | C25H27ClN2O4 |
|---|---|
| Molecular Weight | 454.95 |
| Exact Mass | 454.16600 |
| PSA | 84.50000 |
| LogP | 4.82300 |
|
~64%
Robotnikinin CAS#:1132653-79-2 |
| Literature: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION Patent: WO2009/132032 A2, 2009 ; Location in patent: Page/Page column 107 ; |
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