Nilutamide-d6

Modify Date: 2024-01-08 06:24:28

Nilutamide-d6 Structure
Nilutamide-d6 structure
Common Name Nilutamide-d6
CAS Number 1189477-66-4 Molecular Weight 323.25800
Density N/A Boiling Point N/A
Molecular Formula C12H4D6F3N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nilutamide-d6


Nilutamide-d6 (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the research of metastatic prostatic carcinoma[1][2].

 Names

Name 3-[4-nitro-3-(trifluoromethyl)phenyl]-5,5-bis(trideuteriomethyl)imidazolidine-2,4-dione
Synonym More Synonyms

 Nilutamide-d6 Biological Activity

Description Nilutamide-d6 (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the research of metastatic prostatic carcinoma[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3(1):9-25.

[3]. Ask K, et al. Metabolism of nilutamide in rat lung. Biochem Pharmacol. 2006 Jan 12;71(3):377-85.

 Chemical & Physical Properties

Molecular Formula C12H4D6F3N3O4
Molecular Weight 323.25800
Exact Mass 323.10000
PSA 98.72000
LogP 2.67660

 Synonyms

Nilutamide-d6
Nilandron-d6
Nilandrone-d6
Anandron-d6