(-)-Hardwickic acid

Modify Date: 2024-01-10 15:15:04

(-)-Hardwickic acid structure	Common Name	(-)-Hardwickic acid
	CAS Number	1782-65-6	Molecular Weight	316.435
	Density	1.1±0.1 g/cm3	Boiling Point	427.2±18.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	212.2±21.2 °C

Use of (-)-Hardwickic acid

Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].

Name	(4aR,5R,6R,8aR)-5-[2-(furan-3-yl)ethyl]-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acid
Synonym	More Synonyms

Description	Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Infection Research Areas >> Neurological Disease
References	[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.

Description

Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Infection

Research Areas >> Neurological Disease

References

[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728.

[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.

Density	1.1±0.1 g/cm3
Boiling Point	427.2±18.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	212.2±21.2 °C
Exact Mass	316.203857
PSA	50.44000
LogP	6.56
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.519