WAY-151932

Modify Date: 2024-01-11 19:08:44

WAY-151932 Structure
WAY-151932 structure
Common Name WAY-151932
CAS Number 220460-92-4 Molecular Weight 402.876
Density 1.3±0.1 g/cm3 Boiling Point 630.6±55.0 °C at 760 mmHg
Molecular Formula C23H19ClN4O Melting Point N/A
MSDS N/A Flash Point 335.1±31.5 °C

 Use of WAY-151932


WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

 Names

Name WAY-151932
Synonym More Synonyms

 WAY-151932 Biological Activity

Description WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.
Related Catalog
Target

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)[1]

In Vitro WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV2 receptors in a dose-dependent manner with an EC50 of 0.74±0.07 nM[2].
In Vivo Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED50=0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile[2].
References

[1]. Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800.

[2]. Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 630.6±55.0 °C at 760 mmHg
Molecular Formula C23H19ClN4O
Molecular Weight 402.876
Flash Point 335.1±31.5 °C
Exact Mass 402.124725
LogP 5.50
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.692
Storage condition 2-8℃

 Synonyms

VNA932
[2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl](5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl)methanone
Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-