HIV-1 protease-IN-2

Modify Date: 2024-01-12 11:34:40

HIV-1 protease-IN-2 structure	Common Name	HIV-1 protease-IN-2
	CAS Number	2248124-46-9	Molecular Weight	558.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₄N₄O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 protease-IN-2

HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].

Name	HIV-1 protease-IN-2

Description	HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 2.53 nM (HIV-1 protease)[1]
In Vitro	HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1[1]. HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC50s of 0.27 µM and 0.59 µM for HIV-1NL4-3 and HIVRDRVS, respectively[1].
References	[1]. Zhu M, et al. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem. 2020 Jan 1;185:111866.

Molecular Formula	C₂₇H₃₄N₄O₇S
Molecular Weight	558.65