HDAC6-IN-6

Modify Date: 2024-01-02 18:38:00

HDAC6-IN-6 structure	Common Name	HDAC6-IN-6
	CAS Number	2413603-10-6	Molecular Weight	329.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC6-IN-6

HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].

Name	HDAC6-IN-6

Description	HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
Target	HDAC6:0.025 ± 0. μM (IC50) HDAC1:0.34 ± 0.0 μM (IC50) HDAC:0.55 ± 0.0 μM (IC50) HDAC9:0.57 ± 0.0 μM (IC50) HDAC7:0.65 ± 0.0 μM (IC50) HDAC5:0.85 ± 0.0 μM (IC50) HDAC3:1.22 ± 0.0 μM (IC50) HDAC2:1.57 ± 0.0 μM (IC50) HDAC4:2.24 ± 0.0 μM (IC50)
In Vitro	HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]
References	[1]. Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.

Molecular Formula	C₂₀H₁₅N₃O₂
Molecular Weight	329.35

HDAC6-IN-6

Use of HDAC6-IN-6

Names

HDAC6-IN-6 Biological Activity

Chemical & Physical Properties