DexChlorpheniramine Maleate

Modify Date: 2024-01-03 12:47:18

DexChlorpheniramine Maleate structure	Common Name	DexChlorpheniramine Maleate
	CAS Number	2438-32-6	Molecular Weight	390.86100
	Density	N/A	Boiling Point	379ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₃ClN₂O₄	Melting Point	112-115ºC(lit.)
	MSDS	Chinese USA	Flash Point	183ºC
	Symbol	GHS06	Signal Word	Danger

Use of DexChlorpheniramine Maleate

Dexchlorpheniramine maleate is an antihistamine, with anticholinergic properties, used to treat allergic conditions.

Name	(Z)-but-2-enedioic acid,(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Synonym	More Synonyms

Description	Dexchlorpheniramine maleate is an antihistamine, with anticholinergic properties, used to treat allergic conditions.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology

Boiling Point	379ºC at 760 mmHg
Melting Point	112-115ºC(lit.)
Molecular Formula	C₂₀H₂₃ClN₂O₄
Molecular Weight	390.86100
Flash Point	183ºC
Exact Mass	390.13500
PSA	90.73000
LogP	3.53040
Vapour Pressure	6.04E-06mmHg at 25°C
Storage condition	2-8℃

DexChlorpheniramine Maleate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US6504000

CAS REGISTRY NUMBER :: 2438-32-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H19-Cl-N2.C4-H4-O4

MOLECULAR WEIGHT :: 390.90

WISWESSER LINE NOTATION :: T6NJ BYR DG&2N1&1 &QV1U1VQ -+

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,347,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3667 No. of Facilities: 13 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 422 (estimated) No. of Female Employees: 194 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	36/37/39-45
RIDADR	UN 2811
WGK Germany	3
RTECS	US6504000
HS Code	2933399090

Precursor 1
CAS#:113-92-8 Chlorpheniramin...
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Severe anaphylactic reaction after intracameral antibiotic administration during cataract surgery.

J. Cataract Refract. Surg. 31(3) , 620-1, (2005)

We report a severe anaphylactic reaction that occurred about 5 minutes after 1.0 mg of cefuroxime was injected into the anterior chamber after routine phacoemulsification and intraocular lens implanta...

Aseptic meningitis associated with intravenous administration of dexchlorpheniramine.

Ann. Med. Interne (Paris.) 154(3) , 179-80, (2003)

Drug-induced aseptic meningitis has been reported mainly with the use of nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins and OKT3 antibodies. We describe today a very un...

Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study.

Biomed. Chromatogr. 24(7) , 774-81, (2010)

In the present study a fast, sensitive and robust validated method to quantify chlorpheniramine in human plasma using brompheniramine as internal standard (IS) is described. The analyte and the IS wer...

MFCD00079046

Dextrochlorpheniramine maleate

EINECS 219-450-6

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Dexchloropheniramine maleate

Dexchlorpheniramine (maleate)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [gamma-(4-chlorophenyl)-pyridine-2-propyl](dimethyl)ammonium hydrogen (Z)-maleate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $66/10mM*1mLinDMSO

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DexChlorpheniramine Maleate

Use of DexChlorpheniramine Maleate

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