NVP DPP 728

Modify Date: 2024-01-01 20:24:12

NVP DPP 728 structure	Common Name	NVP DPP 728
	CAS Number	247016-69-9	Molecular Weight	298.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₈N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NVP DPP 728

NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].

Name	6-[2-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile,dihydrochloride
Synonym	More Synonyms

Description	NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	Ki: 11 nM (DPP-IV)[1]
References	[1]. Hughes TE, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38(36):11597-11603.

Molecular Formula	C₁₅H₁₈N₆O
Molecular Weight	298.34
Exact Mass	370.107574
PSA	104.84000
LogP	2.47516

(2S)-1-(Chloroa...

CAS#:207557-35-5

6-[(2-AMINOETHY...

CAS#:202460-48-8

~32%

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365

1-(Chloroacetyl...

CAS#:214398-99-9

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Burkey, Bryan F.; Dunning, Beth E.; Prasad, Kapa; Mangold, Bonnie L.; Russell, Mary E.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2003 , vol. 46, # 13 p. 2774 - 2789

L-Prolinamide

CAS#:7531-52-4

NVP DPP 728

CAS#:247016-69-9

2-Pyrrolidineca...

CAS#:207557-33-3

NVP DPP 728

CAS#:247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746

N/A

CAS#:477290-51-0

NVP DPP 728

CAS#:247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746

(6-Chloro-3-pyr...

CAS#:33252-28-7

NVP DPP 728

CAS#:247016-69-9

Precursor 6
CAS#:207557-35-5 (2S)-1-(Chloroa... CAS#:202460-48-8 6-[(2-AMINOETHY... CAS#:214398-99-9 1-(Chloroacetyl... CAS#:7531-52-4 L-Prolinamide
CAS#:207557-33-3 2-Pyrrolidineca... CAS#:33252-28-7 (6-Chloro-3-pyr...
DownStream 0

3-Pyridinecarbonitrile, 6-[[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino]-, hydrochloride (1:2)

6-{[2-({2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride

6-{[2-({2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride

nvp dpp 728 dihydrochloride

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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