Voacamine

Modify Date: 2024-01-02 11:31:31

Voacamine Structure
Voacamine structure
Common Name Voacamine
CAS Number 3371-85-5 Molecular Weight 704.89700
Density 1.309g/cm3 Boiling Point N/A
Molecular Formula C43H52N4O5 Melting Point 223℃
MSDS N/A Flash Point N/A

 Use of Voacamine


Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].

 Names

Name methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate
Synonym More Synonyms

 Voacamine Biological Activity

Description Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].
Related Catalog
References

[1]. Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.

[2]. Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.

 Chemical & Physical Properties

Density 1.309g/cm3
Melting Point 223℃
Molecular Formula C43H52N4O5
Molecular Weight 704.89700
Exact Mass 704.39400
PSA 99.89000
LogP 6.36470
Index of Refraction 1.674
Storage condition 2-8℃

 Synonyms

Dodecandisaeure-monomethylester
methyl hydrogen dodecanedioate
monomethyl-dodecanedioate
epi-Voacamin
methyl ester of 1,12-dodecanedioic acid,dimethyl ester
Dodecanedioic acid monomethyl ester
11MeOCO undec acid
Voacamine
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