Phosphate Salt of Tricyclic Nucleoside

Modify Date: 2024-01-03 13:56:37

Phosphate Salt of Tricyclic Nucleoside structure	Common Name	Phosphate Salt of Tricyclic Nucleoside
	CAS Number	61966-08-3	Molecular Weight	400.28
	Density	2.2±0.1 g/cm3	Boiling Point	832.8±75.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₇N₆O₇P	Melting Point	N/A
	MSDS	N/A	Flash Point	457.4±37.1 °C

Use of Phosphate Salt of Tricyclic Nucleoside

Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].

Name	triciribine phosphate
Synonym	More Synonyms

Description	Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase
References	[1]. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.

Density	2.2±0.1 g/cm3
Boiling Point	832.8±75.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₇N₆O₇P
Molecular Weight	400.28
Flash Point	457.4±37.1 °C
Exact Mass	400.089630
PSA	200.81000
LogP	-2.83
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.925

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RY8450000

CHEMICAL NAME :: 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D- ribofuranosyl)-

CAS REGISTRY NUMBER :: 61966-08-3

LAST UPDATED :: 198605

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H17-N6-O7-P

MOLECULAR WEIGHT :: 400.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

5-Methyl-1-(5-O-phosphono-b-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine

5-Methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine

Pentaazaacenaphthylene-5' phosphate ester

3-Amino-1,5-dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(Dihydrogen Phosphate)

Phosphate Salt of Tricyclic Nucleoside

Triciribine phosphate (USAN)

1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-

VQD-002

TCN-P

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Triciribine phosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Use of Phosphate Salt of Tricyclic Nucleoside

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