INF 4E
Modify Date: 2024-04-03 16:26:25
INF 4E structure
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Common Name | INF 4E | ||
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| CAS Number | 88039-46-7 | Molecular Weight | 240.68300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H13ClO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of INF 4EINF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2]. |
| Name | ethyl 2-((2-chlorophenyl)(hydroxy)methyl)acrylate |
|---|---|
| Synonym | More Synonyms |
| Description | INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2]. |
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| Related Catalog | |
| In Vitro | INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent mannersup>[3]. |
| In Vivo | INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure[1]. INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way[1]. |
| References |
| Molecular Formula | C12H13ClO3 |
|---|---|
| Molecular Weight | 240.68300 |
| Exact Mass | 240.05500 |
| PSA | 46.53000 |
| LogP | 2.49270 |
| Storage condition | -20°C |
| 2-[hydroxy(2-chlorophenyl)methyl]acrylic acid ethyl ester |
| 2-[(2-Chloro-phenyl)-hydroxy-methyl]-acrylic acid ethyl ester |