EA-230

Modify Date: 2024-02-17 11:25:34

EA-230 Structure
EA-230 structure
Common Name EA-230
CAS Number 503844-09-5 Molecular Weight 373.40500
Density N/A Boiling Point N/A
Molecular Formula C15H27N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EA-230


EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis[1].

 Names

Name (2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylbutanoic acid
Synonym More Synonyms

 EA-230 Biological Activity

Description EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis[1].
Related Catalog
In Vivo EA-230 (30-50 mg/kg; i.p.; twice daily for four consecutive days) improves survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation[1]. Animal Model: Male C57Bl/6 mice, ischemia reperfusion injury model[1] Dosage: 20, 30, 40 or 50 mg/kg Administration: Intraperitoneal injection, twice daily for four consecutive days Result: Improved survival markedly. With doses between 30–50 mg/kg survival reached 56–62%, the low dose treatment with 20 mg/kg did not have a beneficial effect. Significantly increased renal blood flow (RBF), attenuated CTGF up-regulation, enhanced tubular epithelial cell regeneration and attenuated TGF-beta activation.
References

[1]. Gueler F, et al. A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice. PLoS One. 2015 Jan 24;10(1):e0115709.

 Chemical & Physical Properties

Molecular Formula C15H27N5O6
Molecular Weight 373.40500
Exact Mass 373.19600
PSA 205.17000
LogP 1.79640

 Synonyms

L-Valine,L-alanyl-L-glutaminylglycyl