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马来酰肼

马来酰肼用途

Maleic hydrazide广泛用作植物生长调节剂和除草剂。Maleic hydrazide 是核酸和蛋白质合成的抑制剂。
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马来酰肼名称

[ CAS 号 ]:
123-33-1

[ 中文名 ]:
抑芽丹

[ 英文名 ]:
Maleic hydrazide

[中文别名 ]:

[英文别名 ]:

马来酰肼生物活性

[ 描述 ]:

Maleic hydrazide广泛用作植物生长调节剂和除草剂。Maleic hydrazide 是核酸和蛋白质合成的抑制剂。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[体外研究]

顺丁烯二酰肼作为一种致突变剂和致突变剂,仍被用于农业生产。与乙烯利相比,马来酰肼对所有细胞系的IC50值都较低。马来酰肼对Vero细胞的细胞毒性最小,其次是Hep2和HepG2细胞[3]。

[体内研究]

顺丁烯二肼经口、经皮和吸入途径具有较低的急性毒性[3]。

[参考文献]

[1]. Venezian A, et al. The Influence of the Plant Growth Regulator Maleic Hydrazide on Egyptian Broomrape Early Developmental Stages and Its Control Efficacy in Tomato under Greenhouse and Field Conditions. Front Plant Sci. 2017;8:691. Published 2017 May 16.

[2]. Swietlińska Z, et al. Cytotoxic effects of maleic hydrazide. Mutat Res. 1978;55(1):15-30.

[3]. Yurdakok B, et al. Cytotoxic effects of etephon and maleic hydrazide in Vero, Hep2, HepG2 cells. Drug Chem Toxicol. 2014;37(4):459-465.

马来酰肼物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
477.2±25.0 °C at 760 mmHg

[ 熔点 ]:
306-308 ºC

[ 分子式 ]:
C4H4N2O2

[ 分子量 ]:
112.087

[ 闪点 ]:
242.4±23.2 °C

[ 精确质量 ]:
112.027275

[ PSA ]:
65.72000

[ LogP ]:
-0.14

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
6 g/L

马来酰肼MSDS

马来酰肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UR5950000
CHEMICAL NAME :
3,6-Pyridazinedione, 1,2-dihydro-
CAS REGISTRY NUMBER :
123-33-1
LAST UPDATED :
199701
DATA ITEMS CITED :
38
MOLECULAR FORMULA :
C4-H4-N2-O2
MOLECULAR WEIGHT :
112.10
WISWESSER LINE NOTATION :
T6VMMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - increase in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,1,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,173,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,173,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84780 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84780 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 1440 (estimated)
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马来酰肼安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H341

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37/39

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
UR5950000

[ 海关编码 ]:
2928000090

马来酰肼合成路线

马来酰肼上下游产品

马来酰肼制备

由顺丁烯二酸酐与水合肼反应而得。在反应锅中投入水及40%水合肼,搅拌冷却下滴加30%盐酸,温度控制在20℃以下,至pH值为6.2-6.4,投入顺丁烯二酸酐,缓缓升温至106-110℃,回流2h,降温至5℃,甩滤,滤饼用冰水洗至pH4.8-5.1,干燥,得顺丁烯二酰肼,收率97%。

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马来酰肼海关

[ 海关编码 ]: 2933990011

[ 中文概述 ]:
2933990011 抑芽丹,三唑磷,虫线磷,喹硫磷,唑啶草酮等〔包括哒嗪硫磷,亚胺硫磷,氯亚胺硫磷,保棉磷,益棉磷,威菌磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933990011 o,o-diethyl o-quinoxalin-2-yl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

马来酰肼文献

Mixture genotoxicity of 2,4-dichlorophenoxyacetic acid, acrylamide, and maleic hydrazide on human Caco-2 cells assessed with comet assay.

J. Toxicol. Environ. Health A 78(6) , 369-80, (2015)

Assessment of genotoxic properties of chemicals is mainly conducted only for single chemicals, without taking mixture genotoxic effects into consideration. The current study assessed mixture effects o...

Assessment of the chemical, microbiological and toxicological aspects of post-processing water from underground coal gasification.

Ecotoxicol. Environ. Saf. 108 , 294-301, (2014)

The purpose of this paper is to provide a comprehensive characterisation (including chemical, microbiological and toxicological parameters) of water after the underground coal gasification (UCG) proce...

Glyphosate, alachor and maleic hydrazide have genotoxic effect on Trigonella foenum-graecum L.

Bull. Environ. Contam. Toxicol. 88(5) , 659-65, (2012)

In the present study effects of herbicides glyphosate (GP), alachlor (AL) and maleic hydrazide (MH) is studied on mitotic cells of Trigonella foenum-graecum L. Seeds of T. foenum-graecum L. treated wi...


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【马来酰肼】化源网提供马来酰肼CAS号123-33-1,马来酰肼MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询马来酰肼上化源网,专业又轻松。>>电脑版:马来酰肼

标题:马来酰肼_MSDS_用途_密度_马来酰肼CAS号【123-33-1】_化源网 地址:https://m.chemsrc.com/mip/cas/123-33-1_1090894.html