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L-2-噻唑林二酮-4-甲酸

L-2-噻唑林二酮-4-甲酸用途

Oxothiazolidinecarboxylic acid 是一种抗氧化剂,是半胱氨酸的前药,它是惰性的,在细胞内代谢成半胱氨酸,从而刺激谷胱甘肽的合成。
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L-2-噻唑林二酮-4-甲酸名称

[ CAS 号 ]:
19771-63-2

[ 中文名 ]:
丙半胱氨酸

[ 英文名 ]:
Oxothiazolidinecarboxylic acid

[中文别名 ]:

[英文别名 ]:

L-2-噻唑林二酮-4-甲酸生物活性

[ 描述 ]:

Oxothiazolidinecarboxylic acid 是一种抗氧化剂,是半胱氨酸的前药,它是惰性的,在细胞内代谢成半胱氨酸,从而刺激谷胱甘肽的合成。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[体内研究]

恶噻唑烷羧酸治疗可减轻足底萎缩,恢复谷胱甘肽水平,增加过氧化氢酶、铜/锌-SOD1和Mn-SOD2 mRNA表达,但并未降低氧化应激的其他标志物或这些分解代谢因子的水平[1]。动物模型:雄性Sprague-Dawley大鼠(200-250g,n=6-7只/组)[1]。用量:0.35%(w/v)。给药:最后12周以0.35%(w/v)的浓度添加到他们的饮食中。结果:与未补充酒精组相比,纤维CSA增加。

[参考文献]

[1]. Jeffrey S Otis, et al. Procysteine Stimulates Expression of Key Anabolic Factors and Reduces Plantaris Atrophy in Alcohol-Fed Rats. Alcohol Clin Exp Res. 2009 Aug;33(8):1450-9.

L-2-噻唑林二酮-4-甲酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 熔点 ]:
174 °C (dec.)(lit.)

[ 分子式 ]:
C4H5NO3S

[ 分子量 ]:
147.152

[ 精确质量 ]:
146.999008

[ PSA ]:
91.70000

[ LogP ]:
-1.11

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
1.595

[ 储存条件 ]:
室温

L-2-噻唑林二酮-4-甲酸MSDS

L-2-噻唑林二酮-4-甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ5426650
CHEMICAL NAME :
4-Thiazolidinecarboxylic acid, 2-oxo-, (R)-
CAS REGISTRY NUMBER :
19771-63-2
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H5-N-O3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,109,1993
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,164,1992
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,164,1992
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L-2-噻唑林二酮-4-甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XJ5426650

[ 海关编码 ]:
2934999090

L-2-噻唑林二酮-4-甲酸合成路线

L-2-噻唑林二酮-4-甲酸上下游产品

L-2-噻唑林二酮-4-甲酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-2-噻唑林二酮-4-甲酸文献

Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability.

Biomaterials 56 , 114-28, (2015)

Oxidative stress due to increased formation of reactive oxygen species (ROS) in target cells of dental resin monomers like 2-hydroxyethyl methacrylate (HEMA) is a major mechanism underlying the distur...

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions.

J. Antimicrob. Chemother. 68(10) , 2305-10, (2013)

Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in critical care settings. Acinetobacter has become a leading cause of VAP. In particular, the appearance and spr...


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产品详情:L-2-噻唑林二酮-4-甲酸


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