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原花青素C1

原花青素C1用途

Procyanidin C1 是一种天然多酚,可造成 DNA 损伤,细胞周期停滞,诱导凋亡 (apoptosis)。Procyanidin C1 降低癌细胞中 Bcl-2 的蛋白水平,增强 BAX,caspase 3 和 9 的表达。

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原花青素C1名称

[ CAS 号 ]:
37064-30-5

[ 中文名 ]:
原花青素C1

[ 英文名 ]:
Procyanidin C1

[英文别名 ]:

Procyanidol C1
Procyanidin C1

原花青素C1生物活性

[ 描述 ]:

Procyanidin C1 是一种天然多酚,可造成 DNA 损伤,细胞周期停滞,诱导凋亡 (apoptosis)。Procyanidin C1 降低癌细胞中 Bcl-2 的蛋白水平,增强 BAX,caspase 3 和 9 的表达。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[ 靶点 ]

Apoptosis[1]

[参考文献]

[1]. Koteswari LL, et al. A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer. Nat Prod Res. 2019 Jan 8:1-8.

原花青素C1物理化学性质

[ 密度 ]:
1.747g/cm3

[ 分子式 ]:
C₄₅H₃₈O₁₈

[ 分子量 ]:
866.77200

[ 精确质量 ]:
866.20600

[ PSA ]:
331.14000

[ LogP ]:
4.44390

[ 外观性状 ]:
褐色粉末

[ 折射率 ]:
1.826

[ 储存条件 ]:
?20°C

原花青素C1MSDS

原花青素C1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WY9070000

CAS REGISTRY NUMBER :: 37064-30-5

LAST UPDATED :: 199106

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C45-H38-O18

MOLECULAR WEIGHT :: 866.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 200 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

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原花青素C1安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

原花青素C1合成路线

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原花青素C1文献

UHPLC-PDA-ESI/HRMSn profiling method to identify and quantify oligomeric proanthocyanidins in plant products.

J. Agric. Food Chem. 62(39) , 9387-400, (2014)

Oligomeric proanthocyanidins were successfully identified by UHPLC-PDA-HRMS(n) in a selection of plant-derived materials (jujube fruit, Fuji apple, fruit pericarps of litchi and mangosteen, dark choco...

A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential.

Fitoterapia 101 , 169-78, (2015)

Grape seeds are a rich source of polyphenols, especially proanthocyanidins (PACs), and are also known for the presence of galloylated oligomeric PACs (OPACs). The present study focuses on the phytoche...

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