< 生产厂家价格 >

格列苯脲杂质A

格列苯脲杂质A用途

Gitoxin是一种Na+/K+-ATP酶抑制剂,通常由于洋地黄毒素的代谢降解而出现,它只是靠近C-17β位置的羟基(ZOH),这大大改变了这些物质的药代动力学和药效学[1]。

点击显示

格列苯脲杂质A名称

[ CAS 号 ]:
4562-36-1

[ 中文名 ]:
格列苯脲杂质A

[ 英文名 ]:
GITOXIN

[中文别名 ]:

[英文别名 ]:

Gitoksin
Anhydrogitalin
gitoxigenin-tridigitoxosid
Gitoxin (50 mg)
GINSENOSIDES KIT
bigitalin
GITOXIN

格列苯脲杂质A生物活性

[ 描述 ]:

Gitoxin是一种Na+/K+-ATP酶抑制剂,通常由于洋地黄毒素的代谢降解而出现,它只是靠近C-17β位置的羟基(ZOH),这大大改变了这些物质的药代动力学和药效学[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

[参考文献]

[1]. Danijela Krstić, et al. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase. J Enzyme Inhib Med Chem. 2004 Oct;19(5):409-15.

格列苯脲杂质A物理化学性质

[ 密度 ]:
1.36g/cm3

[ 沸点 ]:
932ºC at 760 mmHg

[ 熔点 ]:
265ºC

[ 分子式 ]:
C₄₁H₆₄O₁₄

[ 分子量 ]:
780.94

[ 闪点 ]:
278.6ºC

[ 精确质量 ]:
780.43000

[ PSA ]:
203.06000

[ LogP ]:
2.21810

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.602

[ 储存条件 ]:
室温

格列苯脲杂质AMSDS

详细MSDS(安全技术说明书)

格列苯脲杂质A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ0525000

CHEMICAL NAME :: Gitoxin

CAS REGISTRY NUMBER :: 4562-36-1

BEILSTEIN REFERENCE NO. :: 0077015

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C41-H64-O14

MOLECULAR WEIGHT :: 781.05

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 GQ IQ F- DT5OV EHJ& OO- FT6OTJ B1 DQ CO- FT6OTJ B1 DQ CO- FT6OTJ B1 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 590 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 8,85,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 222 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,364,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4400 ug/kg

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,251,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1210 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 11,613,1963 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,183,1963

点击显示

格列苯脲杂质A安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P260-P262-P280-P302 + P352 + P310-P304 + P340 + P310

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
LZ0525000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29389090

格列苯脲杂质A上下游产品

格列苯脲杂质A上游产品

格列苯脲杂质A下游产品

格列苯脲杂质A文献

A new alternative in the field of cardiac glycosides: gitoxin.

J. Pharm. Belg. 41 , 39-53, (1986)

更多文献