美利蒽

美利蒽用途

美利曲辛(Melitracene)是一种口服活性三环抗抑郁药,也是一种具有激活特性的双极性胸腺肽。美利曲辛抑制3H-5-HT和14H-5-HT,IC50分别为670nm和5500nm。美利曲辛可用于研究抑郁和焦虑[1][2]。

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美利蒽名称

[ CAS 号 ]:
5118-29-6

[ 中文名 ]:
美利蒽

[ 英文名 ]:
Melitracen

[中文别名 ]:

二甲胺丙烯蒽

[英文别名 ]:

Melitracen
Melitracene
Adaptol
Thymeol
Trausabun
Meltiracene
Dixeran

美利蒽生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]

[体外研究]

美利曲辛(0-10μM；10分钟)抑制突触体中的3H-5-HT和血小板中的14H-5-HT[2]。细胞活力测定[2]细胞系：雄性白化大鼠的突触体和血小板浓度：0-10μM孵育时间：10分钟结果：突触体中的3H-5-HT和血小板中的14H-5-HT分别受到抑制,IC50分别为670 nM和5500 nM。

[体内研究]

美利曲辛(10-90 mg/kg；每日口服3个月)影响大鼠的行为、体重和生长[1]。动物模型：雄性和雌性Wistar大鼠[1]剂量：10、30和90mg/kg给药：口服灌胃；每日10-90mg/kg；3个月的结果：随着剂量的增加,大鼠表现出攻击性行为、兴奋性、身体和肝脏重量增加,肝脏轻微萎缩。

[参考文献]

[1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37.

[2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340.

美利蒽物理化学性质

[ 密度 ]:
1.046g/cm3

[ 沸点 ]:
399.1ºC at 760mmHg

[ 分子式 ]:
C₂₁H₂₅N

[ 分子量 ]:
291.43000

[ 闪点 ]:
174.4ºC

[ 精确质量 ]:
291.19900

[ PSA ]:
3.24000

[ LogP ]:
4.70930

[ 折射率 ]:
1.4900 (estimate)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

美利蒽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB0770000

CHEMICAL NAME :: delta-(sup 9(10),gamma)-Anthracenepropylamine, N,N,10,10-tetramethyl-

CAS REGISTRY NUMBER :: 5118-29-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H25-N

MOLECULAR WEIGHT :: 291.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

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美利蒽安全信息

[ 海关编码 ]:
2921499090

美利蒽合成路线

详细合成路线

美利蒽上下游产品

美利蒽上游产品

美利蒽下游产品

美利蒽海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

美利蒽