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安乃近用途

Metamizole (Dipyrone) 钠盐水合物是一种强效的镇痛药物, 抑制环氧合酶 (COX) 。

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安乃近名称

[ CAS 号 ]:
5907-38-0

[ 中文名 ]:
安乃近水合物

[ 英文名 ]:
Analgin

[中文别名 ]:

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[英文别名 ]:

Dipyrone monohydrate
Analgin
Metamizol monohydrate
Noraminopyrine Methanesulfonate Sodium Monohydrate
MFCD00150293
EINECS 200-694-7
Metamizole (sodium hydrate)

安乃近生物活性

[ 描述 ]:

Metamizole (Dipyrone) 钠盐水合物是一种强效的镇痛药物, 抑制环氧合酶 (COX) 。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[参考文献]

[1]. Pierre SC, et al. Inhibition of cyclooxygenases by dipyrone. Br J Pharmacol. 2007 Jun;151(4):494-503.

[相关活性小分子]

安乃近物理化学性质

[ 分子式 ]:
C₁₃H₁₈N₃NaO₅S

[ 分子量 ]:
351.35

[ PSA ]:
95.75000

[ LogP ]:
1.50410

[ 外观性状 ]:
白色或淡黄色结晶粉末,无气味的,微苦

[ 储存条件 ]:
2-8°C

安乃近MSDS

安乃近毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB1320000

CHEMICAL NAME :: Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt, monohydrate

CAS REGISTRY NUMBER :: 5907-38-0

LAST UPDATED :: 199507

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H17-N3-O4-S.H2-O.Na

MOLECULAR WEIGHT :: 352.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 70 gm/kg/25W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1221,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5829 No. of Facilities: 422 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4405 (estimated) No. of Female Employees: 2165 (estimated)

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安乃近安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R63

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
PB1320000

[ 海关编码 ]:
2933192000

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安乃近海关

[ 海关编码 ]: 2933192000

安乃近文献

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The impact of various reactive oxygen species on the formation of neutrophil extracellular traps.

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J. Pharm. Pharmacol. 67 , 1733-43, (2015)

This work was undertaken to assess the antinociceptive and hypoglycaemic properties of a quantified extract of Conyza filaginoides (CFOE), as well as the antinociceptive potential of rutin, the main a...

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