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核苷酸

核苷酸用途

L-Dihydroorotic acid 可通过二氢乳清酶可逆水解产生无环的 L-脲基琥珀酸。

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核苷酸名称

[ CAS 号 ]:
5988-19-2

[ 中文名 ]:
核苷酸

[ 英文名 ]:
L-Dihydroorotic acid

[中文别名 ]:

[英文别名 ]:

(S)-dihydroorotic acid
dihydroorotate
MFCD00085339
(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
L-Dihydroorotic Acid
EINECS 204-352-8

核苷酸生物活性

[ 描述 ]:

L-Dihydroorotic acid 可通过二氢乳清酶可逆水解产生无环的 L-脲基琥珀酸。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. St. Louis, Missouri,et al. ENZYMATIC SYNTHESIS AND BREAKDOWN OF A PYRIMIDINE, OROTIC ACID.October 28, 1953.

核苷酸物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
524.0±60.0 °C at 760 mmHg

[ 熔点 ]:
254-255 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₆N₂O₄

[ 分子量 ]:
158.112

[ 闪点 ]:
270.7±32.9 °C

[ 精确质量 ]:
158.032761

[ PSA ]:
95.50000

[ LogP ]:
-2.29

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.714

[ 储存条件 ]:
Store at 0-5°C

核苷酸MSDS

详细MSDS(安全技术说明书)

核苷酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999001

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核苷酸海关

[ 海关编码 ]: 2934999001

核苷酸文献

SEC-TID: A Label-Free Method for Small-Molecule Target Identification.

J. Biomol. Screen. 19(6) , 917-927, (2014)

Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehen...

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

Biochemistry 47(34) , 8929-36, (2008)

Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here ...

Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.

Hum. Mol. Genet. 21(18) , 3969-83, (2012)

Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, have been identified as the cause of Miller (Genée-We...

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核苷酸