L-亮氨酸
L-亮氨酸用途
L-亮氨酸名称
[ CAS 号 ]:
61-90-5
[ 中文名 ]:
L-亮氨酸
[ 英文名 ]:
L-leucine
[中文别名 ]:
[英文别名 ]:
- MFCD00002617
- Glusate
- H-L-GLU-OH
- Leucine
- L-GLU
- (l)-leucine
- EINECS 200-522-0
- H-GLU-OH
- [14C]-L-(+)-Leucine
- GLU
L-亮氨酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
mTORC1
[体外研究]
[参考文献]
[相关活性小分子]
L-亮氨酸物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
225.8±23.0 °C at 760 mmHg
[ 熔点 ]:
286-288 ºC
[ 分子式 ]:
C6H13NO2
[ 分子量 ]:
131.173
[ 闪点 ]:
90.3±22.6 °C
[ 精确质量 ]:
131.094635
[ PSA ]:
63.32000
[ LogP ]:
0.73
[ 外观性状 ]:
白色结晶粉末
[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C
[ 折射率 ]:
1.463
[ 储存条件 ]:
室温
[ 水溶解性 ]:
22.4 g/L (20 C)
L-亮氨酸MSDS
L-亮氨酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OH2850000
- CHEMICAL NAME :
- Leucine, L-
- CAS REGISTRY NUMBER :
- 61-90-5
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C6-H13-N-O2
- MOLECULAR WEIGHT :
- 131.20
- WISWESSER LINE NOTATION :
- QVYZ1Y1&1 -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5379 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 138 gm/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 6-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 6-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81818 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81818 No. of Facilities: 1037 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 21979 (estimated) No. of Female Employees: 16153 (estimated)
L-亮氨酸安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
OH2850000
[ 海关编码 ]:
29224995
L-亮氨酸合成路线
L-亮氨酸上下游产品
L-亮氨酸上游产品
L-亮氨酸下游产品
L-亮氨酸制备
1.蛋白质(干酪素、角蛋白等)用盐酸或稀硫酸水解,水解液经碱中和沉淀出亮氨酸、L-异亮氨酸及L-蛋氨酸的混合物,用铜盐法精制,用β-萘磺酸使L-亮氨酸沉淀,得纯品。
2.提取法
3.发酵法
4.酶法
5. 烟草:BU,22;FC,21。由谷蛋白、玉米蛋白等蛋白质水解、精制而得。也可用化学方法合成。
L-亮氨酸海关
[ 海关编码 ]: 2922499990
[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐(含有一种以上含氧基的除外). 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
L-亮氨酸文献
J. Virol. 89(10) , 5714-23, (2015)
Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (Rd...
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.J. Nutr. 144(12) , 1977-84, (2014)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa...
Improved characterization of EV preparations based on protein to lipid ratio and lipid properties.PLoS ONE 10(3) , e0121184, (2015)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and qua...
相关化工产品/化学物质:
推荐生产厂家/供应商:
公司名:吉尔生化(上海)有限公司
区域:上海市闵行区
价格:
$需询单/1kg
联系人:杨经理
产品详情:H-Leu-OH
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥108.0/200mg
¥448.0/1kg
¥268.0/500g
¥88.0/100g
联系人:刘佳
产品详情:L-亮氨酸
公司名:南京肽业生物科技有限公司
区域:南京市六合区
价格:
¥需询单/10g
¥需询单/100g
¥需询单/1kg
¥需询单/10kg
联系人:范经理
产品详情:H-Leu-OH
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥389.0/50mg
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:L-Leucine
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥99.0/100g
¥293.0/500g
¥1156.0/2500g
¥37.0/25g
联系人:夏言
产品详情:[Perfemiker]L-亮氨酸,99%生物技术级
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相关化合物
【L-亮氨酸】化源网提供L-亮氨酸CAS号61-90-5,L-亮氨酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询L-亮氨酸上化源网,专业又轻松。>>电脑版:L-亮氨酸
标题:L-亮氨酸_MSDS_用途_密度_L-亮氨酸CAS号【61-90-5】_化源网 地址:https://m.chemsrc.com/mip/cas/61-90-5_895104.html