Gossypin

Gossypin用途

Gossypin 是从 Hibiscus vitifolius 中分离得到的一种黄酮,具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病、镇痛和保护肝脏的活性。Gossypin 抑制 NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,Gossypin 也可抑制 RANKL 诱导的破骨细胞形成。

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Gossypin名称

[ CAS 号 ]:
652-78-8

[ 中文名 ]:
棉纤维素

[ 英文名 ]:
Gossypin

[中文别名 ]:

[英文别名 ]:

Gossypetin 8-O-glucoside
3,3',4',5,7-pentahydroxyflavone-8-O-glucoside
Gossypin
Gossypetin-8-glucoside

Gossypin生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 心血管疾病

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: NF-κB[1]

[参考文献]

[1]. Ajaikumar B Kunnumakkara, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21.

[2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.

Gossypin物理化学性质

[ 密度 ]:
1.883 g/cm3

[ 沸点 ]:
886ºC at 760 mmHg

[ 熔点 ]:
229-230ºC

[ 分子式 ]:
C₂₁H₂₀O₁₃

[ 分子量 ]:
480.37600

[ 闪点 ]:
310.8ºC

[ 精确质量 ]:
480.09000

[ PSA ]:
230.74000

[ 外观性状 ]:
固体

[ 折射率 ]:
1.799

[ 储存条件 ]:
室温

GossypinMSDS

详细MSDS(安全技术说明书)

Gossypin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3009900

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-(beta-D-glucopyranosyloxy)- 3,5,7- trihydroxy-

CAS REGISTRY NUMBER :: 652-78-8

BEILSTEIN REFERENCE NO. :: 0071526

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-O13

MOLECULAR WEIGHT :: 480.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 10,277,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,647,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 26300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,647,1959

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Gossypin安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36-37

[ 危险品运输编码 ]:
NONH for all modes of transport

Gossypin文献

Impact of polyphenolic components from mulberry on apoptosis of vascular smooth muscle cells.

J. Sci. Food Agric. 96 , 381-91, (2015)

Previous studies have shown that mulberry polyphenolic compounds have an anti-atherosclerotic effect in rabbits. Apoptosis of vascular smooth muscle cells (VSMCs) is the key determinant of the number ...

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