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3-磷酸甘油醛脱氢酶

3-磷酸甘油醛脱氢酶用途

用于测定ATP甘油-3-磷酸偶联反应的生化研究，临床上常用作诊断酶，直接测定磷酸甘油酸激酶的活力。

常用诊断用酶。测定ATP甘油醛-3磷酸偶联反应的生化研究，并可直接用于测定磷酸甘油酸激酶的活力

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3-磷酸甘油醛脱氢酶名称

[ CAS 号 ]:
9001-50-7

[ 中文名 ]:
甘油醛磷酸酯脱氢酶

[ 英文名 ]:
Glyceraldehyde phosphate dehydrogenase

[英文别名 ]:

MFCD00131203

3-磷酸甘油醛脱氢酶生物活性

[ 描述 ]:

甘油醛磷酸脱氢酶是抗胸腺细胞和抗凋亡药物的靶点。甘油醛磷酸脱氢酶催化全羟基自由基对还原的烟酰胺腺嘌呤二核苷酸的链氧化[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Chan PC, et al. Glyceraldehyde-3-phosphate dehydrogenase-catalyzed chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals. J Biol Chem. 1980 Feb 10;255(3):874-6.

[2]. Jenkins JL, et al. High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):290-301.

3-磷酸甘油醛脱氢酶物理化学性质

[ 分子式 ]:
C₃H₇O₆P

[ 分子量 ]:
170.057841

[ 外观性状 ]:
suspension | white

[ 储存条件 ]:
2-8°C

3-磷酸甘油醛脱氢酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
B,Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

3-磷酸甘油醛脱氢酶制备

以免肌为原料，经KOH提取、硫酸铵分级分离，再经Sephadex G-50柱层析和CM-Sephadex柱层析，最后硫酸铵沉淀、重结晶而得。

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3-磷酸甘油醛脱氢酶文献

The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species.

Nucleic Acids Res. 12(23) , 9179-89, (1984)

A recombinant M13 clone (O42) containing a 65 b.p. cDNA fragment from human fetal liver mRNA coding for glyceraldehyde-3-phosphate dehydrogenase has been identified and it has been used to isolate fro...

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal. 2 , ra46, (2009)

Protein phosphorylation events during T cell receptor (TCR) signaling control the formation of complexes among proteins proximal to the TCR, the activation of kinase cascades, and the activation of tr...

The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse.

EMBO J. 3(11) , 2627-33, (1984)

In an experiment designed to find sequences common to a skeletal muscle cDNA library and an X chromosome specific library, we have isolated cDNA clones corresponding to glyceraldehyde 3 phosphate dehy...

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