他克莫司
他克莫司结构式
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常用名 | 他克莫司 | 英文名 | Tacrolimus |
|---|---|---|---|---|
| CAS号 | 109581-93-3 | 分子量 | 822.033 | |
| 密度 | N/A | 沸点 | 871.7ºC at 760 mmHg | |
| 分子式 | C44H71NO13 | 熔点 | 127-129° | |
| MSDS | 中文版 美版 | 闪点 | 481ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye.
Invest. Ophthalmol. Vis. Sci. 56(1) , 45-53, (2015) To investigate the effect of FK-506 eye drops on Botulinum toxin B (BTX-B)-induced mouse dry eye.Forty-five CBA/J mice were followed up for 4 weeks after treatment with 0.025% FK-506, vehicle or 0.9% saline eye drops 3 days after intralacrimal glands injectio... |
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Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models.
Arch. Pharm. Res. 38 , 813-25, (2015) 4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC50... |
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Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.
J. Cell Physiol. 230 , 2510-21, (2015) We have shown constitutive expression of the master regulator of osteoblastogenesis, runt-related transcription factor-2 (Runx2), by microglia cells outside bone. Here, we attempted to evaluate the pathological significance of Runx2 in microglial BV-2 cells e... |
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Rapid measurement of tacrolimus in whole blood by paper spray-tandem mass spectrometry (PS-MS/MS).
Clin. Chim. Acta 441 , 99-104, (2015) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides sensitivity and specificity for monitoring tacrolimus drug level in blood, but it requires an LC system and sample preparation, which is not amenable to random access testing typical of immuno... |
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Favorable outcomes of tacrolimus compared with cyclosporine A for GVHD prophylaxis in HSCT for standard-risk hematological diseases.
Ann. Hematol. 93(7) , 1215-23, (2014) Although calcineurin inhibitors (CNIs) with short-term methotrexate (stMTX) constitute standard prophylaxis for graft-versus-host diseases (GVHD) in hematopoietic stem cell transplantations (HSCT), comparative efficacy of cyclosporine A (CsA) and tacrolimus (... |
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Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A.
Transplantation 98(2) , e12-3, (2014)
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Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity.
Transplantation 99(1) , 210-9, (2015) Immunosuppressive therapy with mammalian target of rapamycin inhibitors (mTORi) requires maintenance of an effective inhibition of the alloimmune response, whereas reducing drug-related nephrotoxicity. Therapeutic monitoring is based on mTORi trough levels, w... |
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Preemptive thoracic drainage to eradicate postoperative pulmonary complications after living donor liver transplantation.
J. Am. Coll. Surg. 219(6) , 1134-42.e2, (2014) Thoracic fluid retention after living donor liver transplantation (LDLT) has various negative consequences, including atelectasis, pneumonia, and respiratory distress or failure.We analyzed the clinical impact of preemptive thoracic drainage in 177 patients u... |
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The risk of recurrent IgA nephropathy in a steroid-free protocol and other modifying immunosuppression.
Clin. Transplant. 28(8) , 845-54, (2014) Recurrent glomerulonephritis is an important cause of kidney allograft failure. The effect of immunosuppression on recurrent IgA nephropathy (IgAN) is unclear. We analyzed the impact of steroids and other immunosuppression on the risk of recurrent IgAN post-k... |