大麻二酚结构式
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常用名 | 大麻二酚 | 英文名 | Cannabidiol |
|---|---|---|---|---|
| CAS号 | 13956-29-1 | 分子量 | 314.462 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 463.9±45.0 °C at 760 mmHg | |
| 分子式 | C21H30O2 | 熔点 | 62-63°C | |
| MSDS | N/A | 闪点 | 206.3±23.3 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method.
Sci. Rep. 5 , 17257, (2015) The increasing emergence of multi-drug resistant streptococci poses a serious threat to public health worldwide. Bacteriophage lysins are promising alternatives to antibiotics; however, their narrow lytic spectrum restricted to closely related species is a ce... |
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Pressurized liquid extraction for the determination of cannabinoids and metabolites in hair: Detection of cut-off values by high performance liquid chromatography-high resolution tandem mass spectrometry.
J. Chromatogr. A. 1406 , 192-200, (2015) Hair analysis has become a routine procedure in most forensic laboratories since this alternative matrix presents clear advantages over classical matrices; particularly wider time window, non-invasive sampling and good stability of the analytes over time. The... |
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Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
J. Virol. 89 , 7979-90, (2015) The interleukin-6 homologue (viral interleukin-6 [vIL-6]) of human herpesvirus 8 is implicated in viral pathogenesis due to its proproliferative, inflammatory, and angiogenic properties, effected through gp130 receptor signaling. In primary effusion lymphoma ... |
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Characterization of a phiBP endolysin encoded by the Paenibacillus polymyxa CCM 7400 phage.
FEMS Microbiol. Lett. 362 , fnv098, (2015) Endolysin (gp1.2) from the Paenibacillus polymyxa CCM 7400 temperate phage phiBP has a modular structure consisting of an N-terminal region with a catalytic glycosyl hydrolase 25 domain and a C-terminal cell wall-binding domain. The entire gene of this endoly... |
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Silver oxynitrate, an unexplored silver compound with antimicrobial and antibiofilm activity.
Antimicrob. Agents Chemother. 59 , 4031-9, (2015) Historically it has been accepted, and recent research has established, that silver (Ag) is an efficacious antimicrobial agent. A dwindling pipeline of new antibiotics, combined with an increase in the number of antibiotic-resistant infections, is bringing Ag... |
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Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.
Behav. Pharmacol. 26(3) , 304-14, (2015) Cannabinoid and opioid agonists can display overlapping behavioral effects and the combination of these agonists is known to produce enhanced antinociception in several rodent models of acute and chronic pain. The present study investigated the antinociceptiv... |
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MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol.
Behav. Pharmacol. 26 , 748-65, (2015) Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-methyl-D-as... |
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Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death.
J. Invest. Dermatol. 135 , 1629-37, (2015) Although the global incidence of cutaneous melanoma is increasing, survival rates for patients with metastatic disease remain <10%. Novel treatment strategies are therefore urgently required, particularly for patients bearing BRAF/NRAS wild-type tumors. Targe... |
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Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation.
J. Pharmacol. Exp. Ther. 351(2) , 457-66, (2014) Cannabidiol (CBD) decreases insulitis, inflammation, neuropathic pain, and myocardial dysfunction in preclinical models of diabetes. We recently showed that CBD also improves vasorelaxation in the Zucker diabetic fatty (ZDF) rat, and the objective of the pres... |