(R)-(-)-1-氨乙基膦酸
(R)-(-)-1-氨乙基膦酸结构式
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常用名 | (R)-(-)-1-氨乙基膦酸 | 英文名 | (R)-(1-Aminoethyl)phosphonic acid |
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| CAS号 | 60687-36-7 | 分子量 | 125.06400 | |
| 密度 | 1.475 g/cm3 | 沸点 | 319.2ºC at 760 mmHg | |
| 分子式 | C2H8NO3P | 熔点 | 290ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 146.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Phosphonopeptides, a new class of synthetic antibacterial agents.
Nature 272 , 56, (1978)
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Synthesis and structure-activity relationships of antibacterial phosphonopeptides incorporating (1-aminoethyl)phosphonic acid and (aminomethyl)phosphonic acid.
J. Med. Chem. 29 , 29, (1986) Phosphonodipeptides and phosphonooligopeptides based on L- and D-(1-aminoethyl)phosphonic acids L-Ala(P) and D-Ala(P) and (aminomethyl)phosphonic acid Gly(P) at the acid terminus have been synthesized and investigated as antibacterial agents, which owe their ... |
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Phosphonopeptides as antibacterial agents: rationale, chemistry, and structure-activity relationships.
Antimicrob. Agents Chemother. 15 , 677, (1979) Peptide mimetics with C-terminal residues simulating natural amino acids have been designed as inhibitors of bacterial cell wall biosynthesis. The phosphonopeptide series consisting of various l and d residues of natural amino acids combined with 1-aminoalkyl... |
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Phosphonopeptides as antibacterial agents: metabolism and pharmacokinetics of alafosfalin in animals and humans.
Antimicrob. Agents Chemother. 16 , 306, (1979) The metabolism and pharmacokinetics of a synthetic antibacterial phosphonodipeptide, alafosfalin, have been studied in rats, baboons, and human volunteers. The compound was rapidly absorbed from the injection site after subcutaneous and intramuscular administ... |
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Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies.
Eur. J. Biochem. 259(1-2) , 63-70, (1999) 8-Amino-7-oxopelargonate synthase catalyzes the first committed step of biotin biosynthesis in micro-organisms and plants. Because inhibitors of this pathway might lead to antibacterials or herbicides, we have undertaken an inhibition study on 8-amino-7-oxope... |
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[Kinetic characteristics and enantioselective action of penicillinase in the hydrolysis reaction of N-phenylacetyl derivatives of 1-aminoethylphosphonic acid and its esters].
Biokhimiia 55(6) , 1124-31, (1990) Penicillin acylase from E. coli (EC 3.5.1.11) was found to hydrolyze N-phenylacetylated 1-aminoethylphosphonic acid and its esters. The enzyme preferentially converts the R-form of the substrates: the ratios of the bimolecular rate constants of penicillin acy... |
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Inhibition of alanine racemase by alanine phosphonate: detection of an imine linkage to pyridoxal 5'-phosphate in the enzyme-inhibitor complex by solid-state 15N nuclear magnetic resonance.
Biochemistry 27(14) , 4966-70, (1988) Inhibition of alanine racemase from the Gram-positive bacterium Bacillus stearothermophilus by (1-aminoethyl) phosphonic acid (Ala-P) proceeds via a two-step reaction pathway in which reactivation occurs very slowly. In order to determine the mechanism of inh... |