去甲-BNI 二盐酸盐
去甲-BNI 二盐酸盐结构式
|
常用名 | 去甲-BNI 二盐酸盐 | 英文名 | nor-Binaltorphimine(nor-BNI) |
|---|---|---|---|---|
| CAS号 | 105618-26-6 | 分子量 | 734.70800 | |
| 密度 | 1.63 g/cm3 | 沸点 | N/A | |
| 分子式 | C40H45Cl2N3O6 | 熔点 | 280ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
|
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
PLoS ONE 7(9) , e44344, (2012) Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets. Each of the KNDy neuropeptides has been implicated in re... |
|
|
Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors.
Psychopharmacology 226(3) , 571-8, (2013) The interaction between repeated cocaine exposure and food restriction on sensitization to the stimulatory effects of cocaine has not been characterized.To compare cocaine sensitization in rats free fed and food restricted, and begin to explore the role of th... |
|
|
Kappa opioid regulation of anxiety-like behavior during acute ethanol withdrawal
Pharmacol. Biochem. Behav. 102(1) , 44-7, (2012) Withdrawal is one of the defining characteristics of alcohol dependence, and is often characterized by impaired physiological function and enhanced negative affect. Recent evidence suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system may be a ... |
|
|
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons
Drug Alcohol Depend. 123(1-3) , 277-81, (2012) Background Buprenorphine is an opioid receptor ligand whose mechanism of action is incompletely understood. |
|
|
Ontogenetic differences in ethanol's motivational properties during infancy.
Alcohol 46(3) , 225-34, (2012) Pairing a conditioned stimulus (CS) with ethanol generally produces aversion for that CS in adult rodents. However, infant rats (PD1-PD3) exposed to ethanol demonstrate appetitive reinforcement to ethanol (Nizhnikov, Varlinskaya, Petrov, & Spear, 2006; Petrov... |
|
|
Vasculoprotective effect of U50,488H in rats exposed to chronic hypoxia: role of Akt-stimulated NO production.
J. Appl. Physiol. 114(2) , 238-44, (2013) Impairment of pulmonary endothelium function in the pulmonary artery is a direct result of chronic hypoxia. This study is to investigate the vasculoprotective effects of U50,488H (a selective κ-opioid receptor agonist) and its underlying mechanism in hypoxia-... |
|
|
Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
PLoS ONE 7(11) , e49669, (2012) Exposure of rats to footshocks leads to an enduring behavioral state involving generalized fear responses and avoidance. Recent evidence suggests that the expression of negative emotional behaviors produced by a stressor is in part mediated by dynorphin and i... |
|
|
Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
Am. J. Physiol. Renal Physiol. 305(1) , F52-60, (2013) The role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve (SN) stimulation was studied in anesthetized female rats, using the rat model of isovolumetric bladder contraction. SN stimulation at a fixed frequency of 10 Hz... |
|
|
Central kappa opioid receptors modulate salt appetite in rats
Physiol. Behav. 106(4) , 506-14, (2012) The role of the central opioid system in the control of water and salt intake is complex, with both stimulatory and inhibitory effects having been observed. The aim of the present study was to investigate the participation of the central κ-opioid receptors in... |
|
|
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis.
Respir. Physiol. Neurobiol. 185(2) , 281-6, (2013) The effects of the selective μ-opioid agonist DAMGO and the selective κ-opioid agonist U-50488H on tritiated acetylcholine release ([(3)H]-ACh) and contractile responses to electrical stimulation (ES) were simultaneously determined in isolated bovine tracheal... |