Synthesis and evaluation of novel ellipticines as potential anti-cancer agents

FM Deane, EC O'Sullivan, AR Maguire…

文献索引：Deane, Fiona M.; O'Sullivan, Elaine C.; Maguire, Anita R.; Gilbert, Jayne; Sakoff, Jennette A.; McCluskey, Adam; McCarthy, Florence O. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 8 p. 1334 - 1344

全文：HTML全文

被引用次数: 21

摘要

Drugs that inhibit DNA topoisomerase I and DNA topoisomerase II have been widely used in cancer chemotherapy. We report herein the results of a focused medicinal chemistry effort around novel ellipticinium salts which target topoisomerase I and II enzymes with improved solubility. The salts were prepared by reaction of ellipticine with the required alkyl halide and evaluated for DNA intercalation, topoisomerase inhibition and growth inhibition against 12 ...