Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1, 3, 8-triazaspiro [4.5] decan-4-one ring system

…, J Perumattam, EA Novotny, M Connolly…

文献索引：Mavunkel, Babu J.; Lu, Zhijian; Goehring, R. Richard; Lu, Songfeng; Chakravarty, Sarvajit; Perumattam, John; Novotny, Elizabeth A.; Connolly, Maureen; Valentine, Heather; Kyle, Donald J. Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3169 - 3173

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被引用次数: 20

摘要

A series of pseudopeptides containing alkyl-, cycloalkyl-, aryl-, and aralkyl-substituted 1, 3, 8- triazaspiro [4.5] decan-4-one-3-acetic acids as amino acid surrogates to replace the Pro2- Pro3-Gly4-Phe5 section of the peptide bradykinin B2 receptor antagonist [Pro3, Phe5] HOE 140 (d-Arg0-Arg 1-Pro 2-Pro 3-Gly 4-Phe 5-Ser 6-d-Tic 7-Oic 8-Arg 9) were prepared. These psuedopeptides were examined in vitro for their B2 receptor affinities as well as for their ...