Tetrahedron

Factors affecting O, C and N acetylation of enamines of the type R 1 CO C α H C β H NHR 2

L Kozerski

文献索引：Kozerski,L. Tetrahedron, 1976 , vol. 32, p. 1299 - 1302

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被引用次数: 13

摘要

Acetylation of the title enamino ketones with acetyl chloride was carried out in pyridine or ether with an without base. N-acetyl derivatives were obtained in pure ether, but activation of O and C nucleophilic centers was promoted by the presence of base. Electronic and structural factors governing regioselectivity of reaction are discussed.