A Facile Synthesis of Colchiceine Analogues [4-(1-Acetamido-3-arylpropyl) tropolones]

T Nozoe, K Takase, N Kawabe, T Asao…

文献索引：Nozoe; Takase; Kawabe; et al. Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3099 - 3105

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被引用次数: 7

摘要

The condensation of 4-acetyltropolone with various arenecarbaldehydes gave a wide variety of 4-cinnamoyltropolone derivatives in good yield. The same reaction with 2- furaldehyde and cinnamaldehyde also afforded the corresponding 4-substituted tropolones. These products were converted to their oximes (with hydroxylamine hydrochloride), which in turn were hydro genated over 5% Pd/C in acetic acid and then acetylated with acetic ...