… on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic …

K Hayashi, K Nunami, J Kato, N Yoneda…

文献索引：Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297

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被引用次数: 75

摘要

(4S)-l-Alkyl-3-[[N-(carboxyalkyl) amino] acyl]-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods. Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed. The dicarboxylic acids 3a-n possessing S, S, S configuration showed potent in vitro ACE inhibitory activities with IC, o values of 1.1 X 10-8-1.5 X M. The ...

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Biosynthesis of the Cephalotaxus alkaloids. Investigations o...

[Gitterman, Amy; Parry, Ronald J.; Dufresne, Richard F.; Sternbach, Daniel D.; Cabelli, Michael D. Journal of the American Chemical Society, 1980 , vol. 102, # 6 p. 2074 - 2081]