(4S)-l-Alkyl-3-[[N-(carboxyalkyl) amino] acyl]-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods. Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed. The dicarboxylic acids 3a-n possessing S, S, S configuration showed potent in vitro ACE inhibitory activities with IC, o values of 1.1 X 10-8-1.5 X M. The ...
[Gitterman, Amy; Parry, Ronald J.; Dufresne, Richard F.; Sternbach, Daniel D.; Cabelli, Michael D. Journal of the American Chemical Society, 1980 , vol. 102, # 6 p. 2074 - 2081]
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