Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity

L Giampietro, A D'Angelo, A Giancristofaro…

文献索引：Giampietro, Letizia; D'Angelo, Alessandra; Giancristofaro, Antonella; Ammazzalorso, Alessandra; De Filippis, Barbara; Di Matteo, Mauro; Fantacuzzi, Marialuigia; Linciano, Pasquale; Maccallini, Cristina; Amoroso, Rosa Medicinal Chemistry, 2014 , vol. 10, # 1 p. 59 - 65

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被引用次数: 2

摘要

In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and trans-stilbene, chalcone, and other lipophilic groups were synthesized. They were evaluated for PPARα transactivation activity; all branched derivatives showed an increase of the transcriptional activity of receptor compared to the linear ones. Noteworthy, ...