CHEMICAL The biological action of isosteric compounds often differs only in degree, therefore, we investigated isosteric compounds of 2-amino-5-nitrothiazole and 2-acetamido- Snitrothiazole. The replacement of the sulphur atom of these thiazoles by the CH= CH and CH= N groups gave the isosteric compounds 2-amino-5-nitropyridine, 2-amino-5- nitropyrimidine and their corresponding acetyl derivatives. The in vitro antitrichomonal ...
