Folate antagonists. 16. Antimalarial and antibacterial effects of 2, 4??diamino??6??[(heterocyclic) thio, sulfinyl, and sulfonyl] quinazolines

EF Elslager, P Jacob, J Johnson…

文献索引：Elslager; Jacob; Johnson; Werbel Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 1 p. 129 - 136

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被引用次数: 9

摘要

Abstract The reaction of 5-chloro-2-nitrobenzonitrile with a variety of mercaptoheterocycles provided the corresponding 2-nitro-5-[(heterocyclic) thio] benzonitriles. Reduction to the amine followed by cyclization with chloroformamidine hydrochloride afforded a series of 2, 4- diamino-6-[(hetero-cyclic) thio] quinazolines. Bromination, oxidation, and amidine formation were accomplished with 2, 4-diamino-6-[(4-phenyl-2-thiazolyl) thio] quinazoline (23) to ...