5, 5-Dialkylbarbituric acids, in which one alkyl is ethyl and the other methyl, ethyl, propyl, butyl, isobutyl; iso-amyl and heptyl, have been compared with respect to their hypnotic activity by Carnot and Tiffeneau. The maximum activity was manifested by the butyl, iso-butyl and iso-amyl derivatives, where the hypnotic effect was thrice that of veronal (diethylbarbituric acid). With the heptyl derivative there was a slight falling off in activity to ...
