Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen

…, H Matsuda, M Yoshikawa, I Kawasaki, S Ohta

文献索引：Kurume, Ai; Kamata, Yasuhiro; Yamashita, Masayuki; Wang, Qilong; Matsuda, Hisashi; Yoshikawa, Masayuki; Kawasaki, Ikuo; Ohta, Shunsaku Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 9 p. 1264 - 1269

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被引用次数: 31

摘要

Eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of δ-and γ-ketoamides, respectively. Subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols A, B, and F, respectively, which originated from the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The synthesized ...