Synthesis of pyrroloazepines. Facile synthesis of 2??substituted pyrrole derivatives by the phosgene method

H Cho, S Matsuki, A Mizuno, H Annoura…

文献索引：Cho, Hidetsura; Matsuki, Shinsuke; Mizuno, Akira; Annoura, Hirokazu; Tatsuoka, Toshio Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 87 - 91

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被引用次数: 16

摘要

Abstract A highly convenient method for the synthesis of 2-substituted pyrrole derivatives 7a- c from pyrrole using phosgene was developed. Successively, 7-methyl-6, 7-dihydro-1H, 5H- pyrrolo [2, 3-c] azepine-4, 8-dione 1a and 6, 7-dihydro-1H, 5H-pyrrolo [2, 3-c] azepine-4, 8- dione 1b (aldisin) were synthesized by phosphorus pentoxide/methanesulfonate and polyphosphoric acid cyclization.