Carbon Monoxide??Free One??Step Synthesis of Isoindole??1, 3??diones by Cycloaminocarbonylation of o??Haloarenes Using Formamides

…, YS Wagh, KD Bhatte, BM Bhanage

文献索引：Sawant, Dinesh N.; Wagh, Yogesh S.; Bhatte, Kushal D.; Bhanage, Bhalchandra M. European Journal of Organic Chemistry, 2011 , # 33 p. 6719 - 6724

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被引用次数: 5

摘要

Abstract A new carbon monoxide-free, solvent-free, single step protocol for the synthesis of isoindole-1, 3-diones from o-haloarenes using palladium acetate and xantphos catalysis is reported. The wider applicability of this protocol for several types of o-iodoarenes and a few o-bromoarenes makes it attractive. Aryl iodides and aryl bromides provided moderate to excellent yields of up to 93%.

~93%

~76%

~64%

~71%

~85%

~51%

~47%

~84%

~66%

~54%

~45%

~73%

~45%

~40%

~87%

~71%

~52%

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