Molecular modification of anticholinergics as probes for muscarinic receptors. 2. Amino esters of. alpha.-methyltropic acid

…, HS Jae, JE Gearien, EB Thompson

文献索引：Lu, Matthias C.; Shih, Lisa B.; Jae, Hwan S.; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 424 - 427

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被引用次数: 4

摘要

As a continuation of our goals to study molecular probes for muscarinic cholinergic receptors, a series of 3-substituted 2-methyl-2-phenylpropanoates with the general structure of C6H5C (CH, X)(CH3) COOCH, CH2NEt2 where X= OH, OTs, F, C1, Br, I, and OAc were prepared and their antispasmodic activities examined on isolated rat ileum preparations. Structure-activity relationship studies with these compounds provide further evidence ...