Tetrahedron: Asymmetry

Dynamic kinetic resolution: synthesis of optically active α-amino acid derivatives

SA Brown, MC Parker, NJ Turner

文献索引：Brown, Stuart A.; Parker, Marie-Claire; Turner, Nicholas J. Tetrahedron Asymmetry, 2000 , vol. 11, # 8 p. 1687 - 1690

全文：HTML全文

被引用次数: 69

摘要

Candida antarctica lipase B (Novozyme) is an effective catalyst for the dynamic kinetic resolution of racemic 2-benzyl-4-substituted-5 (4H)-oxazolones, in the presence of an alcohol, yielding optically active N-benzoyl amino acid esters. The reaction has been optimised with respect to the solvent and the effect of a catalytic amount of organic base is investigated.