Chemical Communications

Versatile enantiocontrolled synthesis of (+)-fostriecin

T Esumi, N Okamoto, S Hatakeyama

文献索引：Esumi, Tomoyuki; Okamoto, Nanako; Hatakeyama, Susumi Chemical communications (Cambridge, England), 2002 , # 24 p. 3042 - 3043

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被引用次数: 42

摘要

Fostriecin, a potent protein phosphatase inhibitor and antitumor agent, has been enantioselectively synthesized in naturally occurring form via a versatile route, which also allows one to secure all possible stereoisomeres of the C1–C13 fragment including the C11 stereocenter and the geometry of the Δ12-double bond.