Bis-4-aminobenzamidines: Versatile, Fluorogenic A/T-Selective dsDNA Binders §

…, J Martínez-Costas, ME Vázquez, JL Mascarenas

文献索引：Vazquez, Olalla; Sanchez, Mateo I.; Martinez-Costas, Jose; Vazquez, M. Eugenlo; Mascarenas, Jose L. Organic Letters, 2010 , vol. 12, # 2 p. 216 - 219

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被引用次数: 24

摘要

N 1, N 3-Bis (4-amidinophenyl) propane-1, 3-diamine (BAPPA, R= H) is a bisaminobenzamidine fluorogenic derivative that displays a large increase in its emission fluorescence when bound to the minor groove of specific A/T DNA sites (K d for an AATT site∼ 79±6 nM). Moreover, the structural characteristics of BAPPA allow the easy introduction of functional groups that protrude out of the DNA surface.