Discovery of 1-aryloxyethyl piperazine derivatives as Kv1. 5 potassium channel inhibitors (part I)

…, W Chen, H Chu, J Wei, X Zhang, H Sun, Y Tang…

文献索引：Guo, Xiaoke; Ma, Xianglei; Yang, Qian; Xu, Jing; Huang, Lu; Jia, Jianmin; Shan, Jiaojiao; Liu, Li; Chen, Weilin; Chu, Hongxi; Wei, Jinlian; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 89 - 94

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被引用次数: 3

摘要

Abstract Kv1. 5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation (AF), the most common arrhythmia that threatens human. Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1. 5 inhibitory effects by whole cell patch clamp technique. Six compounds which showed better potency than the positive compound ...