Studies on cardiovascular agents. 6. Synthesis and coronary vasodilating and antihypertensive activities of 1, 2, 4-triazolo [1, 5-a] pyrimidines fused to heterocyclic …

…, Y Shimoji, H Fujita, H Nishino, H Mizuno…

文献索引：Sato, Yasunobu; Shimoji, Yasuo; Fujita, Hiroshi; Nishino, Hiroshi; Mizuno, Hiroshi; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 927 - 937

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被引用次数: 25

摘要

Detoxification and elimination of aromatic hydrocarbons generally proceeds through an initial oxidation of the molecule. There has been considerable study of the effects of enzyme induction on the rate of hydrocarbon hydroxylation. However, this study indicates that induction may also affect the position of the initial oxidation. This factor would modify the metabolic pathways, which could conceivably affect the biological activity and disposition ...