Silver??Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3??Trifluoromethylpyrazoles

…, J Nie, L Sun, Y Zheng, JA Ma

文献索引：Li, Feng; Nie, Jing; Sun, Long; Zheng, Yan; Ma, Jun-An Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6255 - 6258

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被引用次数: 51

摘要

3-Trifluoromethylpyrazole is the core unit of many drugs, agrochemicals, and related candidates.[1] Among them are Celecoxib and Mavacoxib (antiarthritic), SC-560 (antitumor), AS-136A (antiviral), Razaxaban (anticoagulant), as well as DP-23 (insecticidal activity; Figure 1).[2] As a result of the immense usefulness of 3-trifluoromethylpyrazole derivatives, efficient construction of the 3-trifluoromethylpyrazole framework has become the subject of ...