Synthesis and biological evaluation of N-(7-indazolyl) benzenesulfonamide derivatives as potent cell cycle inhibitors

L Bouissane, S El Kazzouli, S Léonce, B Pfeiffer…

文献索引：Bouissane; El Kazzouli; Leonce; Pfeiffer; Rakib; Khouili; Guillaumet Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 4 p. 1078 - 1088

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被引用次数: 92

摘要

We herein describe a new synthesis of N-(7-indazolyl) benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3-chloro-7-indazolyl) benzenesulfonamide, was identified as the most potent with an IC50 of 0.44 μM.