Synthesis of novel 3-cyclohexylpropanoic acid-derived nitrogen heterocyclic compounds and their evaluation for tuberculostatic activity

…, H Foks, K Bojanowski, E Augustynowicz-Kopeć…

文献索引：Gobis, Katarzyna; Foks, Henryk; Bojanowski, Krzysztof; Augustynowicz-Kopec, Ewa; Napiorkowska, Agnieszka Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 137 - 144

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被引用次数: 17

摘要

A series of novel 3-cyclohexylpropanoic acid derivatives and 3-cyclohexylpropanoic acid- derived nitrogen heterocyclic compounds (1–8) have been synthesized and evaluated for tuberculostatic activity. Compounds 1a, 1c, 1e and 1f bearing benzimidazole or benzimidazole-like systems showed the most potent tuberculostatic activity against Mycobacterium tuberculosis strains with MIC values ranging from 1.5 to 12.5 μg/mL. More ...